14B-117

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Question

MCQ on 14B - 16A - 16B

Cephazolin
   A. is a third generation cephalosporin 
   B. doesn’t penetrate the blood brain barrier so cannot be used for neurosurgery 
   C. only covers gram-positive cocci 
   D. is a potent bactericidal agent 
   E. do not require dose adjustment in renal impairment 


Comments

Not sure here...

  • A - F - 1st gen
  • B - F ?? - 1st gen b-lactams do not cross BBB
  • C - F - some gram neg cover
  • D - T
  • E - F

The antibiotic prophylaxis guidelines indicate cephazolin is used in clean neurosurgery with the addition of clindamycin for penetrating trauma. Maybe because the BBB is damaged as part of the process? Anyway B is false, agree with D.

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