15B-127

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Question

Concerning midazolam which is NOT correct:
A. It has a half¬ life of 3 hours 
B. it has no active metabolite
C. its oral bioavailability is 40¬-60%
D. Something about lipid solubility

Comments

ANSWER B

A: INCORRECT. 1.8 to 6.4 hours (mean approximately 3 hours)(drugs.com), elimination half time is 1.9hrs (Stoelting p174)
B: CORRECT: midazolam does have an active metabolite; 1-hydroxymidazolam with ½ the activity of the parent compound (Stoelting, p175)
C: INCORRECT. Bioavailability is 50% after an oral dose (Stoelting, p174-5)

References

Dr mitta 03:05, 13 November 2015 (CST)
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