MB40 [Jul2012] ED95 in regards to neuromuscular blockers means. A. Dose required to cause twitch height depression TO 95% of control value B. Dose required to cause twitch height depression OF 95% of control value C. 95% of patients will be paralysed at this dose
Answer:B almost CORRECT
ED95: MEDIAN dose required for 95% twitch depression, in other words 95% depression of twitch height in 50% of patients, that's why we use 2 X ED95 for intubation
Sugammadex causes effective reversal of: A. Rocuronium B. Vecuronium C. Rocuronium and Vecuronium D. Rocuronium, vecuronium and pancuronium E. None of the above
From Open Anesthesia: According to Miller, potency of a NMBD is best described as the effective dose – “The dose of a neuromuscular blocking drug required to produce an effect (e.g., 50%, 90%, or 95% depression of twitch height, commonly expressed as ED50, ED90, and ED95, respectively“. Thus, the ED95 is the amount of NMBD required to reduce twitch height by 95%. ED95 (mg/kg) of Commonly used NMBDs (Adapted from Table 29-4 in Miller) Rocuronium: 0.31 (0.6-1 mg/kg induction, 1.9 to 3.2x the ED95) Vecuronium: 0.04 (0.1 mg/kg induction, 2.5x the ED95) Pancuronium: 0.07 (0.1 mg/kg induction, 1.4x the ED95) Cisatracurium: 0.04 (0.2 mg/kg induction, 5x the ED95, onset in 2.8 mins (Ref. 1) Note that the reason that rocuronium onset is so rapid is that it is not very potent, thus high concentrations (10-fold higher than for vecuronium and pancuronium) are required.
- Stoelting, 5th ed, p338
- Dr mitta 11:12, 18 November 2015 (CST)