- This page contains PHARMACOLOGY MCQs that were on the July 2012 Primary Exam. (The Physiol MCQs are on another page)
Primary MCQ papers
GP40 If a drug has a Vd of 0.6L/kg, it is reasonable to assume:
- A. It distributes throughout TBW, and is not lipid soluble.
- B. Something about Vd equals body water volume...
GP39 G proteins
- A. binds 4 sites
- B. has 2 alpha subunits
GP38 Which one is not a second messenger:
- A. c-AMP
- B. c-GMP
- C. Ca2+
- D. G Proteins
- E. Nitric oxide
GP36 The units of rate constant k are?
- A mg/min
- B mcg/kg/min
- C min
- D min-1
- E ml-1
- A. mac 6.6%
- B. blood:gas coefficient 0.42
- C. saturated vapour pressure 669 (600mmHg?)
- D. oil:water coefficient 346
- E. ?
- A. is a halogenated methyl ethyl ether
- B. is an enantiomer of enflurane
- C. has a boiling point higher than sevoflurane
- D. is odourless
- A. 2% to hexafluroisopropyl
- B. 0.2%
- C. 0.2% via renal ?conjugation
- D. 0.5% ...
- E. 2% fluoride
- A it is used in high concentrations
- B It is relatively insoluble
- C Reaches equilibrium faster than the more soluble second gas
- D Larger volume
- E because it's MAC is additive with the other agent
- F It is less soluble than the volatile it is mixed with
IN37 Mechanism of IMOBILITY with volatiles / ? specific volatile?:
- A Stimulation of GABAa receptors
- E Stimulation of Glycine receptors
Intravenous Anaesthetic Agents
- A 10%
- B 20%
- C 30%
- E 40%
- A Commercial preparation contains sodium something not carbonate
- E ?
- A. antanalgesic in sub-therapeutic doses
- B. ...
IV28 Propofol prefered to Thio in TIVA because
- A Low therapeutic index
- B T1/2 keo
- C high clearance
- ? something about lipid solubility
also remembered as:
IV28 Propofol is suitable for long infusions mostly thanks to its:
- A. low Vd
- B. high clearance
- C. high plasma protein binding
Local Anaesthetic Agents
Which of the following is not an esther local anaesthetic? sounds similar to LA15
- A. Prilocaine
- B. Procaine
- C. Amethocaine
Other wrong answers
- A. Direct sympathomimetic
- B. Significant dopaminergic central effects
- A. G-prot mediated
- B. Voltage gated K channels
- C. Voltage gated Na channels
- D. Voltage gated Ca channels
- E. Voltage gated Mg channels
Muscle Relaxants and Antagonists
MB40 ED95 in regards to neuromuscular blockers means.
- A Dose required to cause twitch height depression TO 95% of control value
- B Dose required to cause twitch height depression OF 95% of control value
- C 95% of patients will be paralysed at this dose
MB03e Which of the following is NOT metabolised by plasma cholinesterase? (new)
- A. Heroin
- B. Mivacurium
- C. Suxamethonium
- D. Remifentanil
- E. Procaine
MB41 Rocuronium has a volume of distibution of 0.3l/kg. From this information you might expect?
- A low lipid solubility
- B high plasma protein binding
- C distributed in the extracellular space
- D ?
- A 0
- B 20
- C 35
- D 45
- E 60
MB03 In pseudocholineesterase deficiency which two drugs will have a prolonged effect? (options included a combination of):
- A procaine and suxamethonium
- B esmolol & remi
- C remifentanil &mivacurium
- D something and esmolol
- E something and remifentanyl
- A Remifentanil and Procaine
- B Esmolol and suxamethonium
- C mivacurium and ...
- D procaine and suxamethonium
- A Hoffman elimination
- B Hoffman elimination and plasma esterases
- C Hoffman elimination and excretion of metabolites in the urine
- D Hoffman elimination and plasma esterases and excretion of metabolites in the urine
- E ...
MD43 Which of the following NDMR'S are metabolized least?
- A Pancuronium
- B Atracurium
- C Mivacurium
- D ...
Major Analgesics and Opioids
- C ?well absorbed orally
- E refractory respiratory depression may occur with a single dose
- A Transdermal is used as an effect acute pain stategy
- B Plama concentration rises rapidly when injected IV
- C Maybe an option to do with its pKa
- D semisynthetic derivative of thebaine
- E ?
(Edit: I think option A may have read "has been used in the treatment of acute pain")
- A Pethidine affects serotonin reuptake
- B Pethidine causes less nausea and vomiting than morphine
- C ...
Anticholinergics / Antimuscarinics
AH08 Treatment of anticholinergic syndrome?
- A Pyridostigmine
- B Neostigmine
- C Physostigmine
- D Pralidoxime
- E Atropine
PS18which is not true about Midazolam
- A not haemodynamically stable
other options one of which was right!
- A Is a selective alpha-1 antagonist
- B Binds covalently to the alpha receptor
- C Causes bradycardia
- D Is a selective alpha-2 antagonist
- E Increases cardiac output
CD50 Which of the following beta blockers have the highest bioavailability
- A poor substrates for breakdown by COMT
- B cause coronary vasoconstriction
- C are direct acting agents
- D ? increase HR ? decrease HR
- E ?something about bradycardia
CD68 Ventricular fibrillation (VF) in an adult:
- A lignocaine 1.5mg/kg is first line treatment
- B high dose adrenaline (100mcg/kg) improves outcome in "in hospital cardiac arrest"
- C bicarbonate indicated if ph< 7.2
- D vasopressin increase coronary and cerebral perfusion via its action at V1 receptors
- E caution with use of amiodarone as it may cause Torsades
- A is broken down by plasma cholinesterases.
- B has significant membrane stabilising effects
- C has inactive metabolites
- D has minimal sympathomimetic properties
- E is a selective agent
CD64 With regards to SNP toxicitity:
- A treated with sodium thiosulphate
- B treated with GTN
- C one SNP molecule releases four CN- ions
Edit: think this also contained an incorrect answer about minimising methaemoglobin levels or something like that)
- A increases QT interval
- B Widens QRS complex
- A ...
- A blocks ligand gated ion channel
- B peripheral blockade 5HT3
- C blockade 5HT4
- D increases amount of serotonin in CTZ
(I'm pretty sure A said cation channel)
A new antiemetic drug ?neurokinin A exert its antagonist mechanism of action via:
- A Substance P ?
- B ....
MD62 Which of the following is true regarding action on platelets? (new)
- A. Non-selective COX inhibitors act irreversibly
- B. Clopidogrel acts reversibly
- D. Abciximab acts reversibly
- A Affects platelet function
- B Increases the action of vitamin K epoxide reductase
- C ?More effective when given as an intravenous dose
- D Doesn't cross the placenta.
- E Peak effect 36-72 hours following dose
- A. Half life is 12 hours
- B. Used as an antiarrythmic drug
- C. Toxixity produces megaloblastic anaemia due to vitamin B12 defeciency
GP41 Drug given optimally as racemic mixture:
Statistics and Clinical Trials
which is descriptive statistic?
- A. ?
A drug that has reached stage 2 of a clinical trial.
- A looks for pharmacokinetic information
- B to be tested on target population
- C ?
- A more detailed study
- B more data referenced
- C more statistically significant result than source material
- D analysis of the results of ALL trials
- E pooled analysis of other study results