Primary MCQ New Syllabus February 2013
Primary MCQ papers
This page contains MCQs that were on the NEW syllabus February 2013 Primary Exam This and future Primary MCQ papers combine Physiology & Pharmacology MCQS (and MCQs in the new topic areas of Anatomy & Equipment) into a single MCQ paper.
Some 2014A questions as this page is not up and running yet:
The affect of ADH in the kidney
- A. Aquaporin insertion on the basolateral membrane
- B. cause constriction of extraglomerular mesangial cells?
- C. Act on V1A receptors / V2A receptors
Renal blood flow in a 70kg man is
- A. 600 – 650 ml/kidney/min
The epidural space does not contain: (repeat)
- A. Fat
- B. Loose connective tissue
- C. Anterior spinal veins
- D. Posterior spinal veins
- E. Posterior spinal artery
Some questions on Thiopentone’s protein binding:
- A. Aspirin increase the free fraction of thiopentone
The following is not a second messenger (repeat)
- A. G-proteins
- B. ... some second messengers Ca, No, ...
Thiopentone redistribution came up
- A. ?Something about peak concentration in the brain at 90 seconds?
Reason for adding HCL to local anaesthetics include
- A. Improve solubility
Something about naltrexone..
Which agent does act via cAMP
- A. Some sympathomimetics
- B. Dopamine / dopexamine / dobutamine
- D. Isoprenaline
- E. Glucagon
Factors affecting ?prolonging muscle relaxation
- A. Aminoglycosides
Something about beta blockers with sympathomimetic activity ...
The following volatiles increase ICP ...
- A. N2O
- B. Xenon
The least metabolised volatile agent include
- A. Desflurane
- B. N2O
- C. Xenon
Which is an amide LA
- A. Procainamide
- B. Procain
- C. ?Amethocaine / cocaine
- D. Tetracaine
- E. Dibucaine
Renal nervous innervations is mainly from
- A. SNS
- B. PNS
Something about the quicker offset of propofol vs thiopentone
- A. larger clearance
- B. shorter context sensitive plasma elimination (not called CSHT)
Noradrenalins action is first offset / terminated by
- A. COMT
- B. MAO
Fluid & Electrolyte Physiology
- A. ?
- B. ?
- C. HES is completely excreted by the kidney
- D. Dextran 40 is used to improve micro-circulatory flow
RE47 How much oxygen is dissolved in blood (repeat):
- A. 6ml at 3atm 100%
- B. ?
- C. ?
Blood & Immunology
Endocrine & Metabolic Physiology
ADH in the kidney:
- A. works via the V1A receptor to cause vascoconstriction
- B. Inserts aquaporins into the basolateral membrane of the collecting duct.
NU14 Which of the following is TRUE about CSF:
- A. lumbar CSF pressure is 110mmHg
Physiology of Muscle and Neuromuscular Junction
What is the first energy source in muscle?
- a) ATP
- b) Creatine phosphate
Maternal, Foetal & Neonatal Physiology
CM41 What is the difference between tool air and medical air?
- a) ?
- c) tool air has oil mist
- d) tool air has higher fraction of oxygen
- e) tool air has lower fraction of oxygen
NP01 At what level does the spinal cord end in the adult?
- A. S2
- B. T12
- C. L1
- D. L5
NP02 The SVC is formed by what 2 structures?
- A. Brachiocephalic trunk and azygous vein.
- B. Right and left brachiocephalic vein
- C. Internal jugular vein and right subclavian vein.
- repeat* Feb 2013 q 20
20. The following are all second messengers EXCEPT:
- A. Inositol triphosphate
- B. Diacyl glycerol
- C. Calcium
- D. Nitric oxide
- E. G proteins
- a) Inhibits platelet aggregation on the vascular endothelium.
- b) Increases cAMP.
- c) Is a potent vasoconstrictor
- d) Causes Pulmonary hypertension
Which of the following are NOT subject to a high degree of first pass metabolism?
- repeat* Plasma cholinesterase metabolises all of the following except
In a patient who developed peripheral neuritis with isoniazid, more likely to have adverse reaction to
A context insensitive half time means that
- a Subject to organ independent metabolism
- b No active metabolite
- c same time to recovery after cessation of infusion irrespective of duration
- d same rate of fall in plasma concentration after cessation of infusion irrespective of duration
- a is a partial agonist and hence has none of the respiratory depressant or sedative effects of morphine
- b undergoes 6-demethylation by cyp2D6 to exert its main therapeutic effect
- c undergoes 3-demethylation to active metabolite morphine to exert its main therapeutic effect
- d is used as the sole anaesthetic agent in weasels and other mustelids because they possess an ultra-rapid cyp2D6 enzyme
Feb 2013 18. Impurities of nitrous oxide production:
- A. NH3
- B. NO2
- C. NO
- D. N2
- E. all of the above
- a) Increase in ICP at 1 MAC
- b) No increase in ICP up to 1 MAC
Intravenous Anaesthetic Agents
Feb 2013 19. Sodium carbonate (Na2 CO3) is added to sodium thiopentone resulting in:
- A. Change of colour
- B. Decrease pH of solution
- C. Release CO2 from solution
- D. Decrease solubility of solution
- E. Bacteriostatic properties
IV31 After 5 mins of giving thiopentone, amount remaining in brain is:
- a) 5%
- b) 10%
- c) 30%
- d) 50%
- e) 100%
- A. Has a chiral centre
- B. Does NOT need a dose reduction in the elderly
- C. Has active metabolites
- D. Clearance affected in cirrhosis
Local Anaesthetic Agents
Which is the correct order of potency in peripheral nerve blockade
- a) bupiv > ropiv > lignocaine > prilocaine
- b) bupivacaine=ropivacaine> lignocaine> prilocaine
- c) levobupivacaine>lignocaine>prilocaine
- d) Prilocaine> bupivacaine> ropivacaine>lignocaine
Major Analgesics and Opioids
80 year old man on PCA morphine, found obtunded. What’s the most likely cause?
- a) Accumulation of M-3-G
- b) Accumulation of M-6-G
- c) Accumulation of Normorphine
- d) Accumulation of norcodeine.
Which of the following is TRUE about pain
- a) substance P functions as a transmitter
First drug used to treat VF:
- a) Lignocaine
- b) Amiodarone
- c) Adrenaline
- d) Sotalol
Increased sympathetic nervous system stimulation causes:
- a) decreased peristalsis
- b) skin vasodilation
- c) splanchnic vasodilation
- d) something else
- e) vasoconstriction of skeletal muscle
Heart rate increases with:
- A. ?
- B. ?
- C. activation of ventricular baroreceptors
- D. increased atrial stretch
- E. expiration
- a) short PR interval
- b) increased QRS duration
- c) prolonged QT
- d) heightened T-wave
- e) hyperpolarizes the plasma membrane (the wording was definitely "plasma" membrane)
Myocardial work decreases with increasing:
- a) contractility
- b) ejection fraction
- c) preload
- d) aortic compliance
- e) CVP
The last part of the heart to depolarise following atrial depolarisation is:
- a) endocardium at the apex
- b) base of the left ventricle
- c) epicardium at the apex
- d) base of the right ventricle
- e) endocardium of the right ventricle
Muscle Relaxants and Antagonists
Anticholinergics / Antimuscarinics
Feb2013 16. A 25 year old female presents with acute thyrotoxicosis. Which would result in rapid control of her symptoms
Feb2013 17. Proton pump inhibitors have few adverse effects. What is the MOST COMMON side effect?
- A. Dry, non productive cough
- B. nausea and constipation
- C. Myopathy, worse on movement
- D. Visual disturbances
- E. Transient elevation AST, ALT
Which of these is an NMDA receptor antagonist?
- a) dextropropoxyphene
- b) dextrometorphan
- c) dexmetetomidine