Primary MCQ New Syllabus February 2013

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Primary Physiology Black Bank | Primary Pharmacology Black Bank


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This page contains MCQs that were on the NEW syllabus February 2013 Primary Exam
This and future Primary MCQ papers combine Physiology & Pharmacology MCQS
(and MCQs in the new topic areas of Anatomy & Equipment) into a single MCQ paper. 


Some 2014A questions as this page is not up and running yet:

The affect of ADH in the kidney

A. Aquaporin insertion on the basolateral membrane
B. cause constriction of extraglomerular mesangial cells?
C. Act on V1A receptors / V2A receptors

Renal blood flow in a 70kg man is

A. 600 – 650 ml/kidney/min

The epidural space does not contain: (repeat)

A. Fat
B. Loose connective tissue
C. Anterior spinal veins
D. Posterior spinal veins
E. Posterior spinal artery

Some questions on Thiopentone’s protein binding:

A. Aspirin increase the free fraction of thiopentone

The following is not a second messenger (repeat)

A. G-proteins
B. ... some second messengers Ca, No, ...

Thiopentone redistribution came up

A. ?Something about peak concentration in the brain at 90 seconds?

Reason for adding HCL to local anaesthetics include

A. Improve solubility

Something about naltrexone..

Which agent does act via cAMP

A. Some sympathomimetics
B. Dopamine / dopexamine / dobutamine
D. Isoprenaline
E. Glucagon

Factors affecting ?prolonging muscle relaxation

A. Aminoglycosides

Something about beta blockers with sympathomimetic activity ...

The following volatiles increase ICP ...

A. N2O
B. Xenon

The least metabolised volatile agent include

A. Desflurane
B. N2O
C. Xenon

Which is an amide LA

A. Procainamide
B. Procain
C. ?Amethocaine / cocaine
D. Tetracaine
E. Dibucaine

Renal nervous innervations is mainly from


Something about the quicker offset of propofol vs thiopentone

A. larger clearance
B. shorter context sensitive plasma elimination (not called CSHT)

Noradrenalins action is first offset / terminated by


Basic Physiology

Fluid & Electrolyte Physiology

FE39b Colloids:

A. ?
B. ?
C. HES is completely excreted by the kidney
D. Dextran 40 is used to improve micro-circulatory flow

Acid-Base Physiology

Respiratory Physiology

RE47 How much oxygen is dissolved in blood (repeat):

A. 6ml at 3atm 100%
B. ?
C. ?

Cardiovascular Physiology

Renal Physiology

GIT Physiology

Blood & Immunology

Endocrine & Metabolic Physiology

ADH in the kidney:

A. works via the V1A receptor to cause vascoconstriction
B. Inserts aquaporins into the basolateral membrane of the collecting duct.


NU14 Which of the following is TRUE about CSF:

A. lumbar CSF pressure is 110mmHg

Physiology of Muscle and Neuromuscular Junction

What is the first energy source in muscle?

a) ATP
b) Creatine phosphate

Maternal, Foetal & Neonatal Physiology

Clinical Measurement

CM41 What is the difference between tool air and medical air?

a) ?
c) tool air has oil mist
d) tool air has higher fraction of oxygen
e) tool air has lower fraction of oxygen


NP01 At what level does the spinal cord end in the adult?

A. S2
B. T12
C. L1
D. L5

NP02 The SVC is formed by what 2 structures?

A. Brachiocephalic trunk and azygous vein.
B. Right and left brachiocephalic vein
C. Internal jugular vein and right subclavian vein.

General Pharmacology

  • repeat* Feb 2013 q 20

20. The following are all second messengers EXCEPT:

A. Inositol triphosphate
B. Diacyl glycerol
C. Calcium
D. Nitric oxide
E. G proteins

Nitric oxide:

a) Inhibits platelet aggregation on the vascular endothelium.
b) Increases cAMP.
c) Is a potent vasoconstrictor
d) Causes Pulmonary hypertension

Which of the following are NOT subject to a high degree of first pass metabolism?

A Propranolol
B Metoclopramide
C Lignocaine
D Midazolam
E something else that is

  • repeat* Plasma cholinesterase metabolises all of the following except
a Cocaine
b Heroin
c mivacurium
d etomidate
e remifentanil

In a patient who developed peripheral neuritis with isoniazid, more likely to have adverse reaction to

a Aspirin
b Sulphonamides
c Amide local anaesthetics
d thiopentone

A context insensitive half time means that

a Subject to organ independent metabolism
b No active metabolite
c same time to recovery after cessation of infusion irrespective of duration
d same rate of fall in plasma concentration after cessation of infusion irrespective of duration


a is a partial agonist and hence has none of the respiratory depressant or sedative effects of morphine
b undergoes 6-demethylation by cyp2D6 to exert its main therapeutic effect
c undergoes 3-demethylation to active metabolite morphine to exert its main therapeutic effect
d is used as the sole anaesthetic agent in weasels and other mustelids because they possess an ultra-rapid cyp2D6 enzyme

Inhalational Agents

Feb 2013 18. Impurities of nitrous oxide production:

A. NH3
B. NO2
D. N2
E. all of the above


a) Increase in ICP at 1 MAC
b) No increase in ICP up to 1 MAC

Intravenous Anaesthetic Agents

Feb 2013 19. Sodium carbonate (Na2 CO3) is added to sodium thiopentone resulting in:

A. Change of colour
B. Decrease pH of solution
C. Release CO2 from solution
D. Decrease solubility of solution
E. Bacteriostatic properties 

IV31 After 5 mins of giving thiopentone, amount remaining in brain is:

a) 5%
b) 10%
c) 30%
d) 50%
e) 100%

IV30 Propofol:

A. Has a chiral centre
B. Does NOT need a dose reduction in the elderly
C. Has active metabolites
D. Clearance affected in cirrhosis

Local Anaesthetic Agents

Which is the correct order of potency in peripheral nerve blockade

a) bupiv > ropiv > lignocaine > prilocaine
b) bupivacaine=ropivacaine> lignocaine> prilocaine
c) levobupivacaine>lignocaine>prilocaine
d) Prilocaine> bupivacaine> ropivacaine>lignocaine

Major Analgesics and Opioids

80 year old man on PCA morphine, found obtunded. What’s the most likely cause?

a) Accumulation of M-3-G
b) Accumulation of M-6-G
c) Accumulation of Normorphine
d) Accumulation of norcodeine.

Which of the following is TRUE about pain

a) substance P functions as a transmitter


First drug used to treat VF:

a) Lignocaine
b) Amiodarone
c) Adrenaline
d) Sotalol

Increased sympathetic nervous system stimulation causes:

a) decreased peristalsis
b) skin vasodilation
c) splanchnic vasodilation
d) something else
e) vasoconstriction of skeletal muscle

Heart rate increases with:

A. ?
B. ?
C. activation of ventricular baroreceptors
D. increased atrial stretch
E. expiration

Hypokalaemia causes:

a) short PR interval
b) increased QRS duration
c) prolonged QT
d) heightened T-wave
e) hyperpolarizes the plasma membrane (the wording was definitely "plasma" membrane)

Myocardial work decreases with increasing:

a) contractility
b) ejection fraction
c) preload
d) aortic compliance
e) CVP

The last part of the heart to depolarise following atrial depolarisation is:

a) endocardium at the apex
b) base of the left ventricle
c) epicardium at the apex
d) base of the right ventricle
e) endocardium of the right ventricle

Muscle Relaxants and Antagonists


Anticholinergics / Antimuscarinics


Psychotherapeutic Drugs

Endocrine Drugs

Feb2013 16. A 25 year old female presents with acute thyrotoxicosis. Which would result in rapid control of her symptoms

A. Carbimazole
B. Methimazole
C. Radioactive iodine
D. Propothiouracil
E. Iodide (Lugols)

Miscellaneous Drugs

Feb2013 17. Proton pump inhibitors have few adverse effects. What is the MOST COMMON side effect?

A. Dry, non productive cough
B. nausea and constipation
C. Myopathy, worse on movement
D. Visual disturbances
E. Transient elevation AST, ALT 

Which of these is an NMDA receptor antagonist?

a) dextropropoxyphene
b) dextrometorphan
c) dexmetetomidine
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