Primary MCQs-August 2011

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Primary Physiology Black Bank | Primary Pharmacology Black Bank


Primary MCQ papers

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Aug14 | Feb15 | Aug15 | Feb16 | Aug16 |

General physiology

MCQ-Aug11-03 Resting membrane potential in skeletal muscle:

A. Approximately the same as the diffusion potential for potassium
B. Direct effect of Na/K ATPase
C. Mainly due to gibbs donnan effect
D. ?
E. ?

MCQ-Aug11-04 Gibbs-Donnan Effect:

A. explains distribution of charge between intra and extraVASCULAR space
B. explains difference in ionic concentration gradients
C. explains distribution af charge between inta and extracellular spaces
D. ?
E. ?

MCQ-Aug11-05 Na+-K+ ATPase pump

A. Digoxin binds to K+ binding site
B. Stimulated by smaller cell size
C. 2 Na+ out, 3 K+ in
D. ?
E. ?

Fluid & electrolytes

FE11 Question about daily water losses similar to the linked MCQ. Pretty sure all answers were incorrect leaving option "E. none of the above" as the most likely. Can't remember the responses.... anyone?

FE08 Hartmanns is

A. Isotonic
B. Contains Ca 2 mmol/L
C. Contains lactate 5 mmol/L
D. ?

Magnesium is needed for

A ? Na/K ATPase function
B ?

FE04 ECG changes in hyperkalaemia

A. QT prolongation
B. ST depression
C. Absence P wave
D. ?
E. ?

Acid-base physiology

AD24 Buffering by Hb better than by plasma proteins because

A. Hb has 38 carboxyl residues
B. great amount
C. plasma protein pKa near pH of Blood

AD25 If pH is 7, then H+ concentration of pure water is:

A. 0
B. 40 nmol/L
C. 70 nmol/L
D. 100 nmol/L
E. 1000 nmol/L

AD26 Fluid loss from pancreatic fistula with normovolaemia

A. Hyperchloremic metabolic acidosis
B. ?
all other combos

AD27 With pCO2 200 mmHg, what else would you find

A. Hyperkalemia
B. Bradycardia
C. Hypercalcaemia

Respiratory Physiology

MCQ-Aug11-06 Following moderate exercise:

A. Arterial lactate increase
B. Decreased pO2
C. Raised pCO2
D. Increased O2 extraction/ (or was it decreased SvO2?)//decreased O2 extraction i think it said
E. decreased arterial pH

RE05 (compare also RE06) In the upright lung (or something like that):

A. The apical alveolar PCO2 is low (28mmHg)
B. The basal alveolar V/Q is high (approx 3)
C. The apical alveolar V/Q is low (approx 0.6)
D. ?
E. ?

MCQ-Aug11-07 During respiratory cycle:

A. Intrapleural Pressure between -8 and -5 mmHg
B. Tracheal flow sinusoidal
C. Alvelar pressure between -2 to +2 cmH20
D. Intrapleural Pressure is sinusoidal
E. Flow is 5 L/s

RE03 Which of the following increase pulmonary vascular resistance:

A. Hypocarbia
B. Alkalosis
C. Raised pulmonary artery pressure
D. Raised left atrial pressure
E. None of the above

CVS physiology

CV34 Which organ has the highest total oxygen consumption at rest:

A. Heart
B. Brain
C. Liver
D. Skin
E. Kidney

Plus another question straight out of the O2 consumption table regarding the O2/100g/min column

New - Myocardial cells

A Gap junctions at Intercalated Discs

MCQ-Aug11-08 With regards to the coronary circulation flow: (new)

A. Flow is initially maintained in VF if perfusion pressure is maintained
B. There is usually no difference between endocardial and epicardial flow
C. Flow in the left ventricle is lowest at mid-systole
D. Sympathetic stimulation directly decreases flow (or something like that) I thought it was 'increases'
E. ?

CV39 With regards to coarctation of the thoracic aorta: (new)

A. Cardiac output is 1.5x normal
B. Flow in all parts of the body is normal
C. The baroreceptors cease to function
D. Vascular resistance in the lower body circulation is greater than that in the upper body
E. BP in arm and leg equal

CV64 Chronic anaemia causes:

A. Increased stroke volume
B. Increased Mean Arterial Pressure
C. Increased TPR
D. Increased mixed venous PO2

CV53 Baroreceptors are found everywhere except:

A. Carotid body
B. Carotid sinus
C. Vena cava
D. Aortic arch
E. Right atrium

CV73 Normal effects of ageing:

A. Wide pulse pressure
B. Increased aortic elasticity
C. Increased ventricular compliance
D. Increased diastolic pressure
E. ?

CV75 Endothelium produces all except:

B. endothelin
C. prostacyclin
D. nitric oxide
E. ?

CV26 During increased intrathoracic pressure of a Valsalva manoeuvre

A. Diastolic filling of the rights ventricle is decreased
B. Arterial baroreceptor activation produces bradycardia
C. Increased venous pressure augments cardiac output
D. Total peripheral resistance is decreased
E. Arterial blood pressure initially decreases

MCQ-Aug11-09 Which ONE of the following does NOT affect brain blood flow

A. pCO2
B. pH in brain intersitum
C. p02
D. Cerebral activity
E. CSF production

MCQ-Aug11-10 Which of the following happens in diastole:

A. C wave
B. Aortic valve closure
C. T wave in ECG
D. Peak aortic blood flow
E. Second heart sound

Renal physiology

Regarding the kidney:

A. Oxygen consumption higher in medulla than cortex
B. O2 consumption correlates with active transport of sodium
C. Can't remember

I'd say the correct answer is B; O2 extraction is higher in the medulla however O2 consumption is less, as cortical:medullary blood flow is 5:1.
Na+ transport has been shown to closely correlate with O2 consumption as it requires Na/K/ATPase.
Reference: Ganong, Chapter 38

KD02 Which has the greatest renal clearance?

B. Glucose
C. Urea
D. Water
E. Insulin

KD16 Actions of PTH on kidney:

A. Increase Ca reabsorption, decrease PO4 reabsorption
B. Increase Ca and PO43- reabsorption
C. Decrease Both
D. Increase PO43-, decrease Ca

This was divided up by region, 1 answer was collecting duct, the other 3 maybe 4 were for proximally ascending, LoH and DCT.

GI physiology

GI16 Small intestine (or something)

A. More bacteria than large bowel
B. Gastric acid and fast transit time reduce number of bacteria
C. Defence against bacteria is by IgA and cellular immunity
D. Same amount bacteria present in small and large bowel but different types
E. Is sterile

GI21 Not produced in liver

A. Immunoglobilun
B. ?

MCQ-Aug11-11 Sympathetic innervation of the gut comes from:

A. L1-L3
B. T6-S3
C. T2-T12
D. T6-T10
E. ?

Blood & Immunology

BL05 Erythropoietin

A. Secretion stimulated by increase sympathetic activity
B. Stimulates production of megakaryocytes
C. Excreted unchanged in urine
D. Only produced in the liver
E. Production facilitated by metabolic and respiratory acidosis

MCQ-Aug11-12 With regard to the ABO blood system:

A. It refers to red cell antibodies
B. Group O are universal donors as they have no antibodies
C. Groups AB are universal recipients as they have no antibodies in their blood
D. Group A blood has no carbohydrate moiety extending the H antigen
E. ?

MCQ-Aug11-13 Granulocytes :

A. Circulating life 3-5 days
B. Produced in lymph nodes and marrow
C. One nucleus
D. Move via amoeboid movement through tissue
E. Activated by immunoglobulins

Endocrine & metabolic physiology

ED23 Resp quotient in sepsis decreased due to

1. Increase CO2?
2. Fat metabolism
3. Hypoxaemia
4. Elevated Lactate
5. Fever

ED31 Brown fat:

A. Produces ATP and Heat
B. Insulates the thermoreceptors around great vessels of the neck
C. Is autonomically mediated
D. Extramitochondrial uncoupling of oxidative phosphorylation

MCQ-Aug11-14 Actions of insulin:

A. Stimulate hormone sensitive lipase
B. Stimulate lipoprotein lipase
C. ?
D. ?
E. ?


MCQ-Aug11-15 (also Pharm GP11) The NMDA receptor:

A. Glycine required as a modulator for opening of ionic channel
B. Activated by Mg2+
C. Mainly pre-synaptic
D. ?
E. ?

MCQ-Aug11-16 Contents of CSF compared with plasma:

A. K+ 60%
B. Glucose 30%
C. HCO3- 80%
D. Na+ 80%
E. Cl- 80%

Physiology of muscle & NMJ

MU06 Something about smooth muscle contraction

A. Does not require an action potential to contract
B. Has a spike action potential, and not a plateau like ventricular muscle
C. ?
D. ?
E. ?

MU19 Immediate source of energy for muscle contraction:

A. ATP in all muscles
B. Creatine phosphate in smooth, ATP in cardiac
C. ?
D. ?
E. ?

MCQ-feb12-57 With regards the nicotinic NMJ:

A. MEPP increased with hypocalcaemia
B. Random release of acetylcholine occurs
C. MEPP of 5 mV occurs
D. ?
E. ?

Maternal, foetal & neonatal physiology

MF03 Closure of the ductus arteriosus occurs due to:

A. Oxygen mediated smooth muscle constriction
B. Pressure in LA>RA
C. Pressure in aorta > Pulmonary artery
D. Increased systemic SVR
E. Increased prostaglandins

MCQ-Aug11-17 Changes in pregnancy include all except:

A. Increase in O2 consumption by 20%
B. Increase in TLC by 15%
C. Increase in VC by 15%
D. Decrease in FRC by 30%
E. Increase in TV by 20%

Clinical measurement

CM40 Henry's Law states:

A. Number of molecules dissolved in solution proportional to partial pressure of that gas in equilibrium.
B. Boyles law
C. ...Other wrong answers

CM30 Which of the following does not use change in electrical resistance:

A. Thermocouple
B. Bourdon gauge
C. Katharometer
D. Thermistor
E. Strain gauge transducer

MCQ-feb12-68 All of the following pressures are equivalent EXCEPT:

A. 1 Atm
B. 760mmHG
C. 100kpa
D. 102cmH20
E. 100,000 newtons per m2

MCQ-feb12-70 Absolute humidity

A. Measured in g/m3
B. is saturated vapour pressure
C. Measured by hair hygrometer
D. Measured by wet and dry bulb hygrometer
E. Equals water vapour present/vapour present at saturation

MCQ-Aug11-01 SaO2 underestimated in

A. Caboxyhb
B. High bilirubin
D. Sickle cell
E. Fluroscein dye

MCQ-Aug11-02 Speed of Ultrasound waves affected by

A. Frequency
B. Type of Tissue
C. Temperature
D. Wavelength
E. Type of probe
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